Author: Ross, Jeffrey S

Source: Biomarkers in Medicine, Volume 5, Number 3, June 2011 , pp. 319-332(14)

Publisher: Future Medicine

Abstract:

Colorectal cancer (CRC) has been re-classified based on molecular analyses of various genes and proteins capable of separating morphologic types of tumors into molecular categories. The diagnosis and management of CRC has evolved with the discovery and validation of a wide variety of biomarkers designed to facilitate a personalized approach for the treatment of the disease. In addition, a number of new prognostic and predictive individual genes and proteins have been discovered that are designed to reflect the sensitivity and/or resistance of CRC to existing therapies. Multigene predictors have also been developed to predict the risk of relapse for intermediate-stage CRC after completion of surgical resection. Finally, a number of biomarkers have been proposed as specific predictors of chemotherapy and radiotherapy response and, in some instances, drug toxicity. In this article, a series of novel biomarkers are considered and compared with standard-of-care markers for their potential use as pharmacogenomic and pharmacogenetic predictors of disease outcome.

Keywords: biomarker; colorectal cancer; molecular classification; pharmacogenetics; pharmacogenomics

Document Type: Research article

DOI: http://dx.doi.org/10.2217/bmm.11.38

Affiliations: 1: Foundation Medicine Inc., Cambridge, MA, USA and Department of Pathology & Laboratory Medicine, Albany Medical College, Department of Pathology, Mail Code 81, 47 New Scotland Avenue, Albany,NY 12208, USA., Email: rossj@mail.amc.edu

Publication date: 2011-06-01

More about this publication?

• Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine.
• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• Information for Librarians
• E-Access Trials
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• By this author: Ross, Jeffrey S

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers