Blood-based biomarkers of Alzheimer’s disease: challenging but feasible

Authors: Thambisetty, Madhav; Lovestone, Simon

Source: Biomarkers in Medicine, 1 February 2010, vol. 4, no. 1, pp. 65-79(15)


Buy & download fulltext article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.


Blood-based biomarkers present a considerable challenge: technically, as blood is a complex tissue and conceptually, as blood lacks direct contact with brain. Nonetheless, increasing evidence suggests that there is a blood protein signature, and possibly a transcript signature, that might act to increase confidence in diagnosis, be used to predict progression in either disease or prodromal states, and that may also be used to monitor disease progression. Evidence for this optimism comes partly from candidate protein studies, including those suggesting that Amyloid-β measures might have value in prediction and those studies of inflammatory markers that consistently show change in Alzheimer’s disease, and partly from true proteomics studies that are beginning to identify markers in blood that replicate across studies and populations.

Keywords: Alzheimer’s disease; biomarkers; blood; dementia; plasma; transcriptomics

Document Type: Research Article


Affiliations: 1Laboratory of Personality & Cognition, Intramural Research Program, National Institute on Aging (NIA), NIH, USA

Publication date: February 1, 2010

Related content


Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page