The aging immune system and its relationship with cancer

Authors: Foster, Anthony D; Sivarapatna, Amogh; Gress, Ronald E

Source: Aging Health, Volume 7, Number 5, October 2011 , pp. 707-718(12)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

The incidence of most common cancers increases with age. This occurs in association with, and is possibly caused by a decline in immune function, termed immune senescence. Although the size of the T-cell compartment is quantitatively maintained into older age, several deleterious changes (including significant changes to T-cell subsets) occur over time that significantly impair immunity. This article highlights some of the recent findings regarding the aging immune system, with an emphasis on the T-cell compartment and its role in cancer.

Keywords: aging; cancer; immune senescence; T cell

Document Type: Research article

DOI: http://dx.doi.org/10.2217/ahe.11.56

Affiliations: 1: 1National Cancer Institute (NCI), Experimental Transplantation & Immunology Branch (ETIB), 10 Center Dr. 10 CRC, 3-3330 Bethesda, MD 20814, USA

Publication date: 2011-10-01

More about this publication?

Aging Health leading coverage of current and emerging topics relating to the safe and effective management of therapy in the elderly, all subject to rigorous peer review. The journal focuses on the most important advances and highlights their relevance in the clinical setting. The journal has been designed to deliver essential concise information in an easily assimilable format - vital for the increasingly time-constrained professional.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
E-Access Trials
ingentaconnect is not responsible for the content or availability of external websites