Cutaneous melanoma in the elderly: epidemiology and management

Authors: Lam, Bao; Ott, Patrick A; Pavlick, Anna C

Source: Aging Health, 1 June 2010, vol. 6, no. 3, pp. 383-392(10)

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Abstract:

The incidence of melanoma is on the rise and the elderly population disproportionately accounts for the majority of melanoma cases and melanoma-related deaths. Advanced age is an independent adverse prognostic factor. Surgical resection remains the mainstay of treatment; however, elderly patients receive care that is nonconformant with well-established guidelines. Medical therapy options for high-risk and metastatic melanomas remain limited. New treatment approaches targeting the MAPK pathway, c-kit gene aberrations and novel immune-based therapies will pave the road to individualized and more effective treatment for invasive melanoma.

Keywords: BRAF; c-kit; elderly; melanoma; temozolomide; vaccine

Document Type: Research Article

DOI: http://dx.doi.org/10.2217/ahe.10.26

Affiliations: 1Bellevue Hospital Center, New York, NY, USA

Publication date: June 1, 2010

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