Angiotensin receptor blockers: do they protect against dementia and Alzheimer's disease in the elderly?
Author: Dwolatzky, Tzvi
Source: Aging Health, Volume 6, Number 3, June 2010 , pp. 285-287(3)
Publisher: Future Medicine
Abstract:<bold>Evaluation of: Li NC, Lee A, Whitmer RA et al.: Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 340, B5465 (2010).</bold> A large observational study with a relatively long period of follow-up was designed to evaluate whether angiotensin receptor blockers are associated with protection against Alzheimer's disease or dementia. In the almost entirely male study population (mean age: 74 years) with cardiovascular disease, the use of angiotensin receptor blockers was associated with a reduced incidence of Alzheimer's disease and dementia. For patients with these conditions, the use of angiotensin receptor blockers reduced both mortality and the rate of admission to a nursing home. While these results are of great interest, they should be interpreted with great caution, since the findings refer to a rather specific study population and, thus, lack generalizability. Further research involving more heterogeneous samples is necessary.
Document Type: Research article
Publication date: 2010-06-01
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