Authors: Deswal, Anita; Zhang, Lily

Source: Aging Health, Volume 4, Number 2, April 2008 , pp. 157-170(14)

Publisher: Future Medicine

Abstract:

Heart failure with preserved systolic function (HF-PSF) may account for 50% or more of patients with heart failure, occurring more commonly in the elderly with comorbid conditions such as hypertension, diabetes, obesity and coronary artery disease. HF-PSF is associated with high morbidity and mortality. A recent study demonstrated that, although survival improved significantly over time among heart failure patients with reduced ejection fraction, there was no such trend toward improvement among patients with HF-PSF. There exists an urgent need to develop effective treatment strategies, specifically for patients with HF-PSF. Current therapeutic recommendations for HF-PSF are aimed at the symptomatic management as well as the treatment of concomitant comorbidities, including hypertension, atrial fibrillation and myocardial ischemia. In spite of two large, recent studies evaluating therapies for HF-PSF, no specific strategies have been proven to substantially benefit outcomes in patients with HF-PSF. This review evaluates the development of therapeutic strategies for HF-PSF and provides an overview of recently completed and currently ongoing clinical trials in patients with HF-PSF, as well as possible therapeutic targets for future study.

Keywords: angiotensin-converting enzyme inhibitors; angiotensin-receptor blockers; ββ-blockers; diastolic heart failure; elderly; heart failure; preserved ejection fraction; preserved systolic function; treatment

Document Type: Research article

DOI: http://dx.doi.org/10.2217/1745509X.4.2.157

Affiliations: 1: 1Section of Cardiology & Winters Center for Heart Failure Research, Michael E DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, VAMC (111B), 2002 Holcombe Blvd, Houston, TX 77030, USA., Email: adeswal@bcm.tmc.edu

Publication date: 2008-04-01

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• Aging Health leading coverage of current and emerging topics relating to the safe and effective management of therapy in the elderly, all subject to rigorous peer review. The journal focuses on the most important advances and highlights their relevance in the clinical setting. The journal has been designed to deliver essential concise information in an easily assimilable format - vital for the increasingly time-constrained professional.
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