Effect of Narrow-band UVB Phototherapy on Soluble Cell Adhesion Molecules in Patients with Psoriasis Vulgaris

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Abstract:

This study investigated the effect of narrow-band ultraviolet B (NB-UVB) phototherapy on serum levels of the soluble cell adhesion molecules sE-selectin, sP-selectin, sL-selectin and soluble intercellular adhesion molecule-1 (sICAM-1) in 58 patients with psoriasis vulgaris. Psoriasis Area and Severity Index (PASI) scores significantly decreased after treatment, confirming the efficacy of NB-UVB phototherapy. Serum levels of sE-selectin also decreased significantly after treatment, and levels of sICAM-1 showed a significant correlation with PASI score and with levels of sE-selectin. The efficacy of NB-UVB phototherapy in improving psoriatic lesions may be a function of decreased serum levels of E-selectin. These findings emphasize the complex roles of soluble cell adhesion molecules in the immunopathogenesis of psoriasis.

Keywords: NARROW-BAND ULTRAVIOLET B (NB-UVB); PHOTOTHERAPY; PSORIASIS AREA AND SEVERITY INDEX (PASI); PSORIASIS VULGARIS; SOLUBLE CELL ADHESION MOLECULES

Document Type: Research Article

Affiliations: 1: Department of Dermatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 2: Department of Dermatology, Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Wuhan, China 3: Department of Dermatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hubei 430022, China. ljwhbzyy@qq.com

Publication date: July 1, 2010

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