Authors: Wang, J.Y.¹; Gu, Y.S.¹; Wang, J.¹; Tong, Y.²

Source: The Journal of International Medical Research, Volume 36, Number 3, May 2008 , pp. 544-550(7)

Publisher: Field House Publishing

Abstract:

The cellular mechanisms of Leber's hereditary optic neuropathy (LHON) are poorly understood and there is little information on the onset of blindness and neurological degeneration. Here we define the relationship between oxidative stress and LHON pathogenicity at the cellular level. Venous blood was obtained from 14 patients with LHON, 21 asymptomatic maternal relatives and 30 normal individuals (controls). The level of free radicals in blood was assessed as luminol luminescence immediately and at 10 min after addition of phytohaemagglutinin. In LHON patients and their asymptomatic relatives, free radicals increased significantly immediately after adding phytohaemagglutinin compared with baseline and normal controls. After 10 min, however, there were no significant differences between and within the groups. These results suggest that the antioxidant capacity is reduced in the blood of patients with LHON and in asymptomatic relatives, and that oxidative stress plays a significant role in the pathogenesis of LHON.

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Keywords: LEBER'S HEREDITARY OPTIC NEUROPATHY; ANTIOXIDANT CAPACITY; OXIDATIVE STRESS

Document Type: Research article

Affiliations: 1: First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China 2: First Affiliated Hospital, Fujian Medical University, Fuzhou, China

Publication date: 2008-05-01

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