Authors: Ma, Y.H.; Yu, J.B.; Yao, H.P.; Zhan, R.Y.; Zheng, J.S.

Source: The Journal of International Medical Research, Volume 36, Number 2, March 2008 , pp. 308-313(6)

Publisher: Field House Publishing

Abstract:

The aim of this study was to develop a tumour vaccine with the ability to induce and expand higher affinity cytotoxic T lymphocytes and stimulate an effective antitumour immune response. The hypothesis tested was that G422 glioblastoma cells modified with B7-1 and interferon (IFN)-γ genes could serve as a tumour vaccine. It was found that therapeutic subcutaneous immunizations with this tumour vaccine significantly induced a cytotoxic T-cell response and prolonged the survival of female Kuming mice with intracerebral G422 tumour isografts. The data collectively suggested that G422 glioblastoma cells genetically modified with B7-1 and IFN-γ genes could serve as a tumour vaccine.

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Keywords: B7-1; INTERFERON-GAMMA; TUMOUR VACCINE; IMMUNOTHERAPY; GLIOBLASTOMA; INTRACEREBRAL TUMOUR ISOGRAFTS; CYTOTOXIC T LYMPHOCYTES

Document Type: Research article

Affiliations: 1: Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

Publication date: 2008-03-01

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