Authors: Takayama, S.; Takahashi, Y.; Osawa, M.; Iwamoto, Y.

Source: The Journal of International Medical Research, Volume 32, Number 5, September 2004 , pp. 558-562(5)

Publisher: Field House Publishing

Abstract:

A 46-year-old Japanese man with type 2 diabetes mellitus, whose only diabetic complication was simple retinopathy, developed acute painful neuropathy. This presented as paresthesia and hyperesthesia restricted to the abdomen. The patient's haemoglobin A_1c had dropped from 12% to 7.5% within 5 months, following a rapid improvement in glycaemic control. On investigation, there were no indications of disease in the intra-abdominal area. Nerve conduction studies were consistent with mild sensorimotor peripheral and autonomic neuropathy. The patient required medication (mexiletine, sulpiride and imipramine hydrochloride) to control the pain. Four months after presentation, the symptoms showed a dramatic improvement and the treatment for pain relief was discontinued without any recurrence of paresthesia or hyperesthesia in the patient's abdomen. This was a very unusual case of diabetic post-treatment painful neuropathy in which the prominent features were severe pain, paresthesia and hyperesthesia restricted to the abdomen.

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Keywords: TYPE 2 DIABETES; HYPERESTHESIA; PAIN; PARESTHESIA; NEUROPATHY

Document Type: Research article

Publication date: 2004-09-01

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