Authors: Makiura, M.; Akamatsu, H.; Akita, H.; Yagami, A.; Shimizu, Y.; Eiro, H.; Kuramoto, M.; Suzuki, K.; Matsunaga, K.

Source: The Journal of International Medical Research, Volume 32, Number 4, July 2004 , pp. 392-399(8)

Publisher: Field House Publishing

Abstract:

We aimed to develop an animal model for atopic dermatitis. HR-1 hairless mice fed a diet with reduced magnesium and zinc levels were compared with mice fed a standard diet. Skin dryness and wrinkle-like changes, scratching behaviour, decreased skin water content, increased transepidermal water loss and raised blood immunoglobulin E levels were seen in the group receiving the reduced magnesium and zinc diet compared with control mice. There were no significant differences in body weight or the weight of the major organs between the two groups. Haematological examination in both groups was normal apart from increased immunoglobulin E levels in mice fed a reduced magnesium and zinc diet. These mice may be useful models of atopic dermatitis; preparation of the animals is not particularly time consuming, the reproducibility is 100%, and atopic dermatitis symptoms occur even in a specific pathogen-free environment.

Articles that cite this article?

Keywords: ATOPIC DERMATITIS; ANIMAL MODEL; MAGNESIUM; ZINC

Document Type: Research article

Publication date: 2004-07-01

More about this publication?

• The Journal of International Medical Research (JIMR) is a leading peer reviewed journal offering exceptional publication speed for medical, clinical and pre-clinical research. Reviews, case studies, preliminary communications, post-marketing surveillance, pharmacoeconomic and managed care studies are also welcome. Supplements publish symposium proceedings or collections of medical, pre-clinical or clinical data and enquiries from potential sponsors are welcome. JIMR is widely indexed and abstracted, including Medline, Current Contents and Excerpta Medica (EMBASE).
• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Internal Medicine ,  Pharmacology ,  Public Health
• By this author: Makiura, M. ;  Akamatsu, H. ;  Akita, H. ;  Yagami, A. ;  Shimizu, Y. ;  Eiro, H. ;  Kuramoto, M. ;  Suzuki, K. ;  Matsunaga, K.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers