Authors: Takei, M.; Shiraiwa, H.; Omata, S.; Motooka, N.; Mitamura, K.; Horie, T.; Ookubo, T.; Sawada, S.

Source: The Journal of International Medical Research, Volume 32, Number 2, March 2004 , pp. 222-231(10)

Publisher: Field House Publishing

Abstract:

We used a new tactile sensor to measure the elastic properties of skin in patients with systemic sclerosis or Raynaud's phenomenon. The sensor consists of a piezoelectric vibrator with vibration pickup to measure frequency changes when the sensor is placed on the skin. The mean frequency change at the skin surface of the proximal third phalanx in patients with systemic sclerosis was significantly lower than in age- and sex-matched controls. The results in systemic sclerosis patients were statistically correlated to the Modified Rodnan Skin Thickness Score. This technique was also used to measure the therapeutic efficacy of salpogrelate, a new specific serotonin receptor antagonist. A greater mean frequency change was seen after treatment. We conclude that this new tactile sensor is useful for quantitatively measuring skin sclerosis and may help determine the efficacy of therapeutic treatments.

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Keywords: SKIN SENSOR; SKIN HARDNESS; SYSTEMIC SCLEROSIS; RAYNAUD'S PHENOMENON

Document Type: Research article

Publication date: 2004-03-01

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• In this Subject: Internal Medicine ,  Pharmacology ,  Public Health
• By this author: Takei, M. ;  Shiraiwa, H. ;  Omata, S. ;  Motooka, N. ;  Mitamura, K. ;  Horie, T. ;  Ookubo, T. ;  Sawada, S.

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