Authors: Ozmen, S.; Yavuz, L.; Ceylan, B Gokce; Tarhan, O.; Aydin, C.

Source: The Journal of International Medical Research, Volume 30, Number 5, September 2002 , pp. 520-524(5)

Publisher: Field House Publishing

Abstract:

The aim of this study was to evaluate the effects of granisetron and granisetron plus droperidol combination therapy on post-operative nausea and vomiting (PONV) in 60 patients who had undergone elective laparoscopic cholecystectomy. Induction of anaesthesia was achieved using 5 mg/kg thiopentone, 2 μg/kg fentanyl and 0.5 mg/kg atracurium, and anaesthesia was maintained with 2 - 2.5% sevoflurane. The patients were randomly assigned to two groups: group G (granisetron) (n = 30) patients received 3 mg granisetron and group GD (granisetron plus droperidol) (n = 30) patients received 3 mg granisetron and 1.25 mg droperidol shortly before the induction of anaesthesia. PONV incidence was recorded post-operatively at 15 min, 30 min, 60 min, 2 h, 4 h, 12 h and 24 h. While PONV prophylaxis provided almost complete emetic control in patients who received the granisetron plus droperidol combination, patients who received granisetron prophylaxis alone experienced PONV more frequently at 30 min and 60 min post-operatively. We conclude that addition of a low dose of droperidol to granisetron prophylaxis is more effective than granisetron prophylaxis alone for successful control of PONV.

Articles that cite this article?

Keywords: GRANISETRON; DROPERIDOL; POST-OPERATIVE NAUSEA AND VOMITING (PONV)

Document Type: Research article

Publication date: 2002-09-01

More about this publication?

• The Journal of International Medical Research (JIMR) is a leading peer reviewed journal offering exceptional publication speed for medical, clinical and pre-clinical research. Reviews, case studies, preliminary communications, post-marketing surveillance, pharmacoeconomic and managed care studies are also welcome. Supplements publish symposium proceedings or collections of medical, pre-clinical or clinical data and enquiries from potential sponsors are welcome. JIMR is widely indexed and abstracted, including Medline, Current Contents and Excerpta Medica (EMBASE).
• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Internal Medicine ,  Pharmacology ,  Public Health
• By this author: Ozmen, S. ;  Yavuz, L. ;  Ceylan, B Gokce ;  Tarhan, O. ;  Aydin, C.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers