Efficacy of Eprinomectin and Doramectin Against Amblyomma americanum (Acari: Ixodidae) on Cattle

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Abstract:

Steers were treated with doramectin or eprinomectin by daily oral capsule for 28 consecutive days. The level of doramectin in the serum of steers treated at 200 μg/kg/d reached a maximum of 104.0 ± 22.1 ppb at day 21 and declined from 93.3 ± 20.5 ppb on the final day of treatment to below detectable by day 56. Steers treated at 50 μg/kg/d reached a maximum level of doramectin in the serum of 24.7 ± 1.2 ppb on day 21 and declined from 24.7 ± 0.6 ppb on the final day of treatment to less than detectable on day 42. Both doramectin dosages provided 100% control of estimated larvae (EL) of Amblyomma americanum (L.) (Acari: Ixodidae) throughout the 28-d treatment period. Daily oral treatment with eprinomectin at a dosage of 200 μg/kg for 28 consecutive days produced a maximum concentration in the serum of 41.6 ± 11.0 ppb at day 14. On the final day of eprinomectin treatment, the serum concentration was 38.3 ± 5.9 ppb. Seven days later at day 35, eprinomectin was not detectable in the serum. For steers treated at 50 μg/kg/d for 28 consecutive days, the serum level of eprinomectin reached a maximum of 10.0 ± 3.0 ppb on day 28 and was undetectable on day 35. Both eprinomectin dosages provided complete control of EL of A. americanum during the 28-d treatment period. Because eprinomectin is efficacious against A. americanum at lower serum levels in cattle and is eliminated from the serum at a more rapid rate than either doramectin or ivermectin, it provides advantages for use in applications such as the medicated bait for control of ticks on white-tailed deer and could have potential for use in the Cattle Fever Tick Eradication Program.

Keywords: acaricidal activity; macrocyclic lactones; oral treatment

Document Type: Research Article

DOI: http://dx.doi.org/10.1603/029.102.0244

Publication date: April 1, 2009

More about this publication?
  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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