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German Cockroach (Dictyoptera: Blattellidae) Gut Contents Inhibit Cytochrome P450 Monooxygenases

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German cockroach, Blattella germanica (L.), gut contents inhibited cytochrome P450-catalyzed methoxyresorufin O-demethylation and aldrin epoxidation. Inhibitory activity was associated mainly with midgut contents of nymphs. However, midgut content preparations from both nymphs and adults were inhibitory to methoxyresorufin O-demethylase activity when evaluated in vitro. A direct relationship between food consumption and loss of enzyme activity in final instar male nymphs was observed when microsomes were prepared with midgut contents in situ. Cytochrome c reductase activity was increased in the presence of midgut contents. These data suggest that the inhibitory factor is possibly a digestive enzyme or some other entity released into the midgut in response to feeding. Furthermore, it emphasizes the importance of gut cleaning before microsome preparation to ensure accurate assays of cytochrome P450 monooxygenase activity in German cockroaches.

Document Type: Research Article

Publication date: December 1, 1996

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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