Possible Mechanism of Diazinon Negative Cross-Resistance in Pyrethroid-Resistant Horn Flies (Diptera: Muscidae)

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The underlying mechanism responsible for enhanced toxicity of the organophosphate diazinon in eight pyrethroid-resistant horn fly, Haematohia irritans (L.), field populations was investigated. In vitro enzyme assays and in vivo pyrethroid synergist studies showed increased activity of the mixed function oxidase system (measured as O-demethylase activity) in five of the eight populations with, in most instances, a subsequent increase in diazinon metabolism. We suspect that enhanced toxicity of diazinon (or negative cross-resistance), as observed in pyrethroid-resistant horn fly field populations, may result from in vivo accumulation of the toxic metabolite diazoxon.

Document Type: Research Article

Publication date: June 1, 1995

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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