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Inhibition of ATP Dephosphorylation by Acaricides with Emphasis on the Anti-ATPase Activity of the Carbodiimide Metabolite of Diafenthiuron

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3-(2,6-Diisopropyl-4-phenoxyphenyl)-I-tert-butylcarbodiimide(DFCD), a toxic metabolite and photodegradation product of the propesticide diafenthiuron, and dicyclohexylcarbodiimide (DCCD). a commonly used biochemical inhibitory probe, inhibited Mg• Na+K+-.and Ca2+Mg2+-ATPaseactivities in preparations from bulb mites (Rhizoglyphus echinopus (Fumouze and RobinĀ», twospotted spider mites (Tetranychus urticae Koch). and bluegill (Lepomis maC1'ochirus Rafinesque) brain. DCCD was more active than DFCD, but neither carbodiimide was very potent. A possible exception occurred with DCCD, which caused 100% inhibition of bulb mite oligomycin-sensitive Mg2+-ATPaseactivity at a concentration of 0.1 mM. Using house fly. Musca domestica L., thorax mitochondrial Mg2+- ATPase, we showed that the binding domain for both carbodiimides was in the F0 portion of the enzyme, probably the transmembrane proton channel which is the known site of DCCD binding in proton-translocating ATPases. Certain other specific acaricides were inhibitors (>50% at 0.1mM) of ATPasepreparations from bulb mites. These acaricides included chloropropylate, and ovex, chlorbenside. and propargite (Mg2+-ATPase).The role of ATPase inhibition in the modes of acaricidal and insecticidal actions of diafenthiuron, the two carbodiimides, and the other compounds is discussed.

Document Type: Research Article

Publication date: June 1, 1991

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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