Neriifolin and 2' -Acetylneriifolin: Insecticidal and Cytotoxic Agents of Thevetia thevetioides Seeds

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A bioassay procedure utilizing the European corn borer, Ostrinia nubilalis (Hübner), has been used to guide the phytochemical fractionation of active extracts of the seeds of a yellow oleander, Thevetia thevetioides (HBK.) K. Schum. (Apocynaceae). The known cardiotonic glycosides, neriifolin and 2'-acetylneriifolin, were crystallized as the active insecticidal agents, giving LD50 determinations of 30 ppm and 192 ppm, respectively, when incorporated into the corn borer diet. These compounds also exhibited cytotoxic activities of 2.2×10−2 and 3.3 × 10−2 g/ml, respectively, in the KB (human nasopharynx epidermoid carcinoma) in vitro system. The glucoside of -sitosterol also was isolated but it lacked insecticidal activity.

Document Type: Research Article

Publication date: June 1, 1980

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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