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Atrazine Inhibition of Carbofuran Metabolism in the House Cricket

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The metabolism of ring-labeled [14C] carbofuran was studied in Acheta domesticus (L.) which has been pre-exposed to 10, 20, and 30 ppm of atrazine for a month. Most of the carbofuran could be extracted from the cricket body. Excretion of carbofuran is not an important defense mechanism in the cricket. Degradation of carbofuran was inhibited in the presence of atrazine, especially when the concentration of atrazine was 30 ppm. The inhibition occurred at the level of the hydroxylation of cabofuran at its carbon-3 position. The results support the hypothesis that compounds capable of blocking the microsomal electron flow can potentate the toxicity of certain insecticides, possibly by inhibition of the microsomal detoxification process.

Document Type: Research Article

Publication date: October 1, 1977

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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