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Anticholinesterase Activity and Toxicity of Substituted Phenyl Methylcarbamates to Honey Bee

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Abstract:

The effect of substitution by alkyl, methoxy, and chloro groups in phenyl methylcarbamates on toxicity to Apis mellifera L. and inhibition of bee head cholinesterase. was examined. Application of Main's kinetic treatment to inhibition of bee head cholinesterase showed that differences in anticholinesterase activity were mainly attributable to differences in affinity rather than carbamylation. The carbamylation constant k2 was found to be independent of electronic effects produced by the substituents. The relation between anticholinesterase activity and synergized toxicity to the honey bee, a carbamate-susceptible insect, was similar to that previously found with house flies. Some carbamates of low anticholinesterase activity were unexpectedly toxic to bees.

Document Type: Research Article

Publication date: February 1, 1977

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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