Metabolism of 14C-Diazinon by Gypsy Moth Larvae

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The metabolic fate of diazinon in larvae of Porthetria dispar (L.) was determined using 14C-ring-labeled material. Following a 4–h ingestion period, 28.7% of the total recovered activity was present as diazinon in the larvae and 0.2% in the feces at 1 h; by 12 h these amounts had changed to 1.4 and 15.4%, respectively. The major transformation products were 2, isopropyl-4-methyl-6-pyrimidinol > diazoxon > hydroxydiazinon > 2-(2′-hydroxy-2′- propyl) -4-methyl-6-pyrimidinol. Small amounts of 5 additional products were detected but were not identified. Metabolism of topically applied diazinon was the same qualitatively as that of ingested diazinon, based on a comparison of chloroform-extractable metabolites, although quantitative differences were evident. The synergists 2,6-dichlorobenzyl-2-propynyl ether (GA4-282) and piperonyl butoxide (PB) altered the metabolism of diazinon (both ingested and topical doses) by apparently similar actions, resulting in a reduction in the formation of 2-isopropyl-4-methyl-6-pyrimidinol, hydroxydiazinon, and 2-(2′-hydroxy- 2′-propyl) -4-methyl-6-pyrimidinol.

Document Type: Research Article

Publication date: October 15, 1975

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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