Oxythioquinox Acaricide: Toxicological Studies with Twospotted Spider Mites1,2

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Abstract:

Oxythioquinox acaricide was highly toxic to Tetranychus urticae Koch, with n 24-hour LC50 of 3.1ppm. Spider mites rapidly hydrolyzed the compound to 6-methyl-2:3-quinoxalinedithiol (QDSH). itself a toxic ant, and to other unidentified polar metabolites both in vivo and in vitro. Using equilibrium dialysis, it was shown that oxythioquinox was; irreversibly bound to bovine serum albumin and to proteins in the spider mite homogenate, rat brain, liver, and blood. Binding was blocked by sulfhydryl reagents and Triton X-100. It was suggested that binding of oxythioquinox to proteins probably involved a mechanism by which the sulfhydryl group of proteins initially attacked the carbonyl carbon of the acaricide. The acaricidal action of oxythioquinox may be due, in part, to disruption of the normal function of significant proteins by the parent compound itself and perhaps by QDSH.

Document Type: Research Article

Publication date: October 1, 1973

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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