Carbaryl Synergism by Substituted 1,3-Benzodioxoles and Related Compounds and Inhibition of Mixed Function Oxidase1

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Abstract:

Several new 1,3-benzodioxole derivatives were synthesized and examined for synergism of carbaryl toxicity to houseflies,Musca domestica L., and for inhibition of aldrin epoxidation by rat liver microsomal oxidase. Synergism data for several of the derivatives confirmed predictions made earlier by another worker. Several of the 4,5-disubstituted- 1,3-benzodioxoles were outstanding in their effectiveness in synergizing the toxicity of carharyl. A direct relationship between synergistic activity and inhibition of microsomal aldrin epoxidation was not observed. Data on inhibition of microsomal oxidase revealed that the catechols are often more potent inhibitors than the related 1, 3-benzodioxoles.

Document Type: Research Article

Publication date: June 1, 1973

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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