Toxicity and Anticholinesterase Activity of Phenyl Methylcarbamate Insecticides to Chrysomya megacephala1 and Phaenicia cuprina1,2
Authors: RESPICIO, NAPOLEON C.; SHERMAN, MARTIN
Source: Journal of Economic Entomology, Volume 65, Number 6, December 1972 , pp. 1535-1542(8)
Publisher: Entomological Society of America
Abstract:Relative topical toxicity of sewn carbamate insecticides: Bay 37344 (1. (methylthio) -3.5-xylyl methylcarbamate) ; Chevron RE-5353 (m-see-butylphenyl methylcarbamate); Chevron RE-5353 (a mixture (4:1) of m- (1- methylbutyl) phenyl methylcarhabamate and m- (l-ethylpropyl) phenyl methylcarhamate); Chen-on RE-5655 (5-see butyl-2-chlorophenyl methycarbamate); propoxur; SD- 8530 (4:1 mixture of 3.4.5- and 2,3.5-trimelhylphenyl methylcarbamate) : and UC-10854 (m-cumellyl methylcarbamate) to mature 3rd-stage larvae and 3- to 4-day-old females of Chrysomya megarcephala (F.) and Phaenicia cuprina (Wiedemann) was investigated. The in vitro and in vivo anticholinesterase activities of these insecticides also were determined.
The 3rd,stage larvae of C. megacephala and P. cuprina were less susceptible to the insecticides than the corresponding adult females. Generally, the larvae of C. megacephala were more susceptible than the larvae of P. cuprina to all the insecticides except Bay 37344.
The natural head cholinesterase activity as measured by the amount of head brei causing 80% hydrolysis of acetylcholine chloride in 30 minutes was C. megacephala 9.0 mg and P. cuprina 6.0 mg.
This study indicates that toxic compounds such as Bay 37344 and propoxur were relatively poor in vitro inhibitors of heat! cholinesterase. On the other hand, RE- 5350, RE-5353, and RE-5655, which were only moderately effective toxicants to both fly species, were more effective enzyme inhibitors. This fact suggests that there was no correlation between toxicity and in vitro cholinesterase inhibition.
In vivo cholinesterase inhibition occurred in all treated flies. However, at LD 50 dosages, relatively low in vivo cholinesterase inhibition occurred, particularly in C. megacephala. Recovery of C. megacephala head enzyme activity was complete or nearly complete 48 hours after treatment. Although some recovery also occurred P. cuprna 48 hours after treatment, it was usually less than that found in C. megacephala No correlation was found between toxicity and in vivo cholinesterase inhibition.
Document Type: Research Article
Publication date: December 1, 1972
- Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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