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Modification of Carbary I Metabolism in Rats with Monoamine Oxidase Inhibitors1

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The rate of carbaryl metabolism by rats was decreased by simultaneously administering drugs commonly referred to as monoamine oxidase inhibitors and by prolonged exposure of the animals to one of the drugs in the drinking' water. Conjugative mechanisms of metabolism were affected most by the drugs although oxidative and hydroxylative metabolism rates were reduced to some degree. Decreasing the rate of metabolism resulted in a slower rate of excretion of the carbamate from rats treated with the drugs. Tranylcypromine at 50 mg/kg, e.g., reduced excretion of carbaryl-14C equivalents from rats by 50% during the 1st 48 hours after treatment. A rat intestine enzyme system, fortified with UDPGA, conjugated 1-naphthol but did not metabolize carbaryl. This in vitro conjugating system was inhibited by the monoamine oxidase inhibitors. The effect of these drugs on conjugation was not sufficient to suggest that they might enhance the action of pesticides under practical conditions, However, the data do demonstrate that conjugation enzyme systems are sensitive to certain foreign chemicals and that more effective inhibitors of conjugation could be important in the safety and efficacy of chemicals used to control insect pests.

Document Type: Research Article

Publication date: August 1, 1972

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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