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House Fly Microsomal Oxidation of Some Foreign Compounds

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Competitive inhibition of aldrin epoxidation by O-dealkylation of p-nitroanisol and methoxychlor; hydroxylation of photoisodrin, photodieldrin, aniline, and hexobarbital; and hydrolysis of parathion indicates that all these reactions take place at the same site on Musca domestica L. microsomal oxidase. These reactions are inhibited by very low concentrations of sesamex. The mixed function oxidase apparently also performs O-dehydrochlorination of photoaldrin, photodieldrin, and photoheptachlor, and hydrolysis of the WARF-antiresistant (N,N-dibutyl-p-chlorobenzenesulfonamide). The gene, Ox, controlling the activity of the mixed function oxidase is located on chromosome 2 in the dimetilan-selected and the Orlando DDT-resistant strains of the house fly.

Document Type: Research Article

Publication date: December 15, 1970

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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