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Changes in Glucose Metabolism Associated with Resistance to DDT and Dieldrin in the House Fly

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Abstract:

Strains of Musca domestica L. in which resistance to DDT depends on the gene kdr-O (for knockdown resistance-Orlando) and strains resistant to dieldrin and other cyclodiene insecticides have approximately twice the normal level of glucose-6-phosphate dehydrogenase (G-6-PD) activity. When the resistance genes were transferred from 1 house fly population to another by appropriate genetic procedures, the high G-6-PD level was similarly transferred. Thus, resistance and high G-6-PD activity are apparently inseparable.

In other tests the metabolism of :4C-labeled glucose was compared in several fly strains, both without insecticidal treatment and after treatment with DDT or dieldrin. In all cases, treatment stimulated glucose metabolism with the effect being greater on metabolism via the pentose pathway.

The results confirm and extend previous findings in which DDT was shown to increase glucose utilization in insects, and in addition they suggest that changes in ability to metabolize glucose may be a factor in insect resistance to chlorinated insecticides.

Document Type: Research Article

Publication date: December 15, 1970

More about this publication?
  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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