To analye the joint action of bunary mixtures, a lab- oratory culture of organophosphorus-susceptible boll wee- vils . Authonomous grandis Boheman. were exposed to in- secticides, defoliants, and equitoxic insecticide-defoliant mixture. The degree of interaction in a susceptible strain of boll weevils was greater than unity for equiloxic binary mixtures of DEF® (S.S,S-tributyl phosphorotrithioate) with methyl parathion. azinphosmethyl, malathion, and EPN®, (O-ethyl O-p-nitrophenyl phenylphosphonothioate) indicating potentiation of toxicity. It was not possible, however to attribute significance to the numerical degree of interaction since the mechanism of potenliation in these mixtures is unknown, The potentiation of methyl parathion by DEF was not supported by stalistical evidence, indicating that the addition of DEF may not necessarily result in greater-than-additive toxicity. The potentiating effects of DEF with malathion have previously been attributed largely to inhibition of aliestnase, a type of carboxyesterase, Conversely, EPN, azinphosmethyl, and methyl parathion lack carboxylic ester moieties, and the importance of aliesterase is questionable.
Document Type: Research Article
Publication date: April 1, 1970
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