Action of Nicotine on Neural Synaptic Transmission in the American Cockroach1,2

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The blocking action of nicotine on the neutral synapse in the 6th abdominal ganglion of Periplaneta Americana (L.), is diphasic. Synaptic transmission was reversibly blocked in the presence of nicotine. The duration of block was dependent on method of application and independent of the concentration. The duration of recovery also was dependent on method of application and independent of concentration. Based on these observations a hypothesis is developed suggesting that the effects of nicotine present the possibility of different types of postsynaptic receptors and that a part of the total effect maybe mediated through the release of synaptically active material.

Document Type: Research Article

Publication date: February 1, 1970

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