Relationship Between Structure of Several Azodrin® Insecticide Homologues and Their Toxicities to House Flies, Tested by Injection, Infusion, Topical Application, and Spray Methods with and without Synergise1
Authors: SUN, YUN-PEI; JOHNSON, E. R.
Source: Journal of Economic Entomology, Volume 62, Number 5, October 1969 , pp. 1130-1135(6)
Publisher: Entomological Society of America
Abstract:Azodrin® insecticide (3-hydroxy-N-methyl-cis-crotonamide dimethyl phosphate) and 6 homologues were tested against Musca domestica L. by topical application, injection, infusion, and oil-spray methods with and/or without a synergist. Their observed toxicities obtained by different testing methods generally decreased from low to high homologues. When the results obtained by topical application and injection methods are compared on the same basis, the difference in toxicities is about 340 times between -NH2 and -NHC8H17 homologues by topical application, and only 2.8 times (M ratio) by injection of flies pretreated with sesamex (synergist) This tremendous change of observed toxicity indicates that by injecting toxicants into flies pretreated with sesamex, the potential toxicity of compounds can be more fully indicated; however, some detoxication may still occur in the higher homologues.
Since homologues of Azodrin insecticide are partitioned more favorably into water than into hexane, the decrease in toxicity by an infusion method, as compared with injection results, is more likely due to detoxication than to partition into lipids. Thus the difference in toxicity between infusion and injection methods would indicate the degree of instability of these compounds in house flies and should correlate with the degree of synergism. When the degree of synergism of Azodrin homologues was plotted against the LD50 ratio of infusion and injection on log-log scales, a straight-line relationship was obtained. Further study on the interaction between physical, chemical, and biological factors is necessary for a better understanding of the relationship between structure and activity.
Document Type: Research Article
Publication date: October 1969
- Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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