Some Biochemical Characteristics of the Microsomal Cyclodiene Epoxidase System and Its Inheritance in the House Fly1

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Musca domestica L. microsomal NADP.H oxidizing system can epoxidise aldrin, isodrin, and heptachlor at identical rates. When any 2 or all 3 of these substrates are incubated with microsomes, there is competitive inhibition of epoxidation of one by the other, showing that they all compete for the same binding site on the enzyme. There is competitive inhibition of aldrin epoxidation by naphthalene hydroxylation and vice versa, showing that both of these microsomal oxidations are carried out by the same enzyme system. Polar organic solvents stimu- lated the microsomal epoxidation of aldrin. Methoxyethanol and isopropanol gave the highest activity even at low solvent concentrations. Ethanol and methanol, showing very low activity at their lower concentrations, gave maximum activity at highest concentrations, while acetone could increase it to only half the maximum. The gene for miuosomal epoxidase (Ox) is situated on chromosome II, at about 32 units from the gene for DDT-dchy- drochlorinase (Deh ) , which is about 8 units from the marker stubby wing (stw).

Document Type: Research Article

Publication date: April 1, 1969

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