Histological Studies of Ovaries in Rats Treated with Hydroxyurea, Triphenyltin Acetate, and Triphenyltin Chloride

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Three insect chemosterilants, hydroxyurea, triphenyltin acetate, and triphenyltin chloride, were tested to determine their effect on ovarian tissue in the albino rat. The compounds were administered orally at dosage rates of 40 mg per kg per day for hydroxyurea, and 20 mg per kg per day for the 2 organotin compounds for periods of 4, 9, 14, 19, and 24 days. Animals were killed on the day following cessation of treatment and histological preparations of ovaries were made and evaluated.

Hydroxyurea had no significant effect on the ovarian tissue and no side effects were detected. However, both triphenyltin compounds produced significant changes in the ovarian tissue. Among these changes were a decreased number of mature follicles, an increased incidence of atresia in early follicle growth, and a pronounced decrease in the number of corpora lutea present. This last effect was regarded as a decrease in ovulation, and thus, a decreased fertility. This effect, as well as the others listed above, was present on or by the 1st 5-day sample period.

Document Type: Research Article

Publication date: December 16, 1968

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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