Possible Pleiotropism of a Gene Conferring Resistance to DDT, DDT Analogs, and Pyrethins in the House Fly1and >Culex tarsalis2,3,4

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A strain of house flies. Musca domestica L., possessing the third chromosomal DDT resistance gene kdr-O (knockdown-resistance-Orlando) was tolerant to several DDT analogs, to pyrethrins, and to pyrethins:piperonyl butoxid mixtures. When DDT resistance due to kdr-O was introduced by crossing over into susceptible strains possessing third chromosomal visible mutants, resistance to pyrethrins:piperonyl butoxide and to the DDT analogs also was introduced. Conversely, introduction of resistance to pyrethrins:piperonyl butoxide into a susceptible strain possessing a third chromosomal marker resulted in a strain resistant to DDT and DDT analogs. Thus, resistance to these insecticides was inseparable, and the gene kdr-O apparently confers resistance to DDT, DDT analogs, and pyrethrins:piperonyl butoxide.

A strain of Culex tarsalis Coquillet, which possessed a kdr-O-like DDT resistance, was shown to be resistant to pyrethrins and pyrethrins:piperonyl butoxide mixtures. Breeding experiments demonstrated that resistance to DDT and pyrethrins in C. tarsalis were genetically linked.

These results suggest pleiotropy in that kdr-O in the house fly confers resistance not only to DDT but to DDT analogs and pyrethrins. Resistance to DDT and pyrethrins in C. tarsalis is possibly controlled also by a similar mechanism.

Document Type: Research Article

Publication date: June 1, 1968

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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