Metabolism of C14.Labeled Carbamate Insecticides to C14O2 m the House Fly1,2
Authors: METCALF, R. L.; OSMAN, M. F.; FUKUTO, T. R.
Source: Journal of Economic Entomology, Volume 60, Number 2, April 1967 , pp. 445-450(6)
Publisher: Entomological Society of America
Abstract:The absorption, metabolism to C14O2, and excretion by several strains of house flies, Musca domestica L., were evaluated for 9 insecticidal carbamates labeled with C14 in various parts of the molecule. The absorption and metabolism to C14O2 was not appreciably different in a susceptible and in 2 carbamate-resistant strains of flies. However, the rate of conversion of the various labeled carbamates to C14O2 was highly specific for the individual carbamates and for the position of labeling. Detoxication of the carbamates was demonstrated to occur through N-dealkylation, S-dealkylation, O-dealkylation, and hydrolysis. The synergists piperonyl but oxide, 2- (3,5-dichlorobiphenyloxy) -triethylamine, and isobornylthiocyano acetate materially decreased the rate of formation of C14O2 from the isopropoxy side chain of 2-isopropoxyphenyl N-methyl carbamate.
Document Type: Research Article
Publication date: April 1, 1967
- Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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