DDT Resistance in Culex tarsalis Coquillett: Cross Resistance to Related Compounds and Metabolic Fate of a C¹⁴-labeled DDT Analog

Authors: PLAPP, FREDERICK W.; CHAPMAN, GARY A.; MORGAN, JOSEPH W.

Source: Journal of Economic Entomology, Volume 58, Number 6, December 1965 , pp. 1064-1069(6)

Publisher: Entomological Society of America

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Abstract:

Larvae of a highly DDT-resistant strain of the mosquito Culex tarsalis Coquillett were resistant also to dehydrochlorinatible analogs of DDT and to nondehydrochlorinatible analogs such as Prolan® (1,1-bis(p-chlorophenyl)-2-nitropropane) and to o-chloro DDT (1,1,1-trichloro-2-(4-chlorophenyl)-2-(2,4-dichlorophenyl) ethane. Combinations of DDT and synergists known to block dehydrochlorination failed to overcome resistance. Certain analogs of DDT in which the hydrogen atom on carbon no. 2 was replaced by less easily oxidized groups largely overcame resistance, that is, were about equally toxic to larvae of susceptible and resistant strains.

Experiments with a C¹⁴-labeled sample of TDE indicated that both susceptible and resistant larvae detoxified the insecticide by dehydrochlorinative and oxidative routes. The results suggest that resistance to DDT and related compounds in C. tarsalis involves a mechanism other than dehydrochlorination. The precise nature of an alternative mechanism was not demonstrated and the nature of the resistance factor must be considered unknown.

Document Type: Research article

Publication date: 1965-12-01

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Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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