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Chemosterilant Properties, Cytotoxicity, and Mammalian Toxicity of Apholate and Other P-N Ring Chemicals

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Chemosterilant activity in the house fly, Musca domestica L., cytotoxicity to mouse fibroblast cells grown in tissue culture, and acute oral toxicity in mice were determined for a series of P-N ring chemicals related to apholate. There was a positive correlation between percent ethylene imine in the molecule, water solubility, and degree of insect sterility. Substituents on the P-N ring also had a marked influence on sterilant activity. Mammalian toxicity was related to percent aziridine on the ring and the type of substituent. The cell toxicity test was not sufficiently selective for highly active insect sterilants; nevertheless none of the active insect sterilants were missed by this method.

Document Type: Research Article

Publication date: October 1, 1965

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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