Mechanism of Detoxication and Synergism of Bidrin Insecticide in House Flies and Soil

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With C11-labeled BidrinĀ® insecticide (3-hydroxy-N,N-dimethyl-cis-croton-amide dimethyl phosphate), some studies have been made on its detoxication by house flies, Musca domestica L., and its stability in soil.

House flies were treated topically with tagged Bidrin with and without the synergist sesamex. Two hours after treatment, the following effects were observed with synergist: increase in knockdown from 10 to 15% to nearly 100%; no significant effect on absorption; considerable reduction in the excretion of radioactive compounds; lower degree of metabolism of Bidrin; the absence of 1 route of metabolism. One of the metabolites found in a significant quantity in the absence of synergist, but very little when synergist was present, was identified as the highly toxic compound 3-hydroxy-N-methylcrotonamide dimethyl phosphate (SD 9129).

Bidrin was quickly detoxified in soil. However, considerable stabilization of Bidrin in soil was observed when treated with 500 ppm of sesamex, chloropicrin, NemagonĀ® soil fumigant (l,2-dibromo-3-chloropropane), chloromycetin, acti-dione, Shell 345 Soil FungicideĀ® (diacetoxy propene) or O,O,O-trimethyl phosphorothioate (SD 4741). Detoxication of Bidrin was also greatly reduced in sterilized or “air dry” soil.

Document Type: Research Article

Publication date: October 1, 1965

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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