Effects of Insecticides on Reproduction in the Laboratory Mouse: I. Kepone

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KeponeĀ® (decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd] pentalen-2-one), a chlorinated organic insecticide, was included in the diet of a mixed lot of laboratory mice totaling 66 pairs at 0, 10, 17.5, 25, 30, and 37.5 ppm for 1 month before and 5 months after mating, to determine the effects on reproductive success. In a 2nd test, a total of 48 pairs of mice of the pure inbred BALB/c strain was fed 0, and 10 ppm for 1 month before mating and 4 months after mating. This was followed by a 3rd test involving 24 control pairs and 36 pairs on 5 ppm Kepone. Reproduction was reduced at all feeding levels, and was expressed by a decrease in the size and number of litters. The greater the concentration of insecticide in the diet, the greater was the effect. A 4th experiment with progeny of the animals used in the 3rd test also showed decreased reproductive success.

Document Type: Research Article

Publication date: August 1, 1965

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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