Detoxication of Dimetilan in Cockroaches and House Flies
Authors: ZUBAIRI, M. YAMEEN; CASIDA, JOHN E.
Source: Journal of Economic Entomology, Volume 58, Number 3, April 1965 , pp. 403-409(7)
Publisher: Entomological Society of America
Abstract:Dimetilan-C14 (2-dimethylcarbamoyl-3-methyl-5-pyrazolyl dimethylcarbamate-carbonyl-C14) is rapidly metabolized in Blattella germanica (L.) to yield 9 C14-labeled metabolites. Six of these metabolites are formed also in Periplaneta americana (L.) and 4 in Musca domestica L. Metabolites tentatively identified include 2-dimethylcarbamoyl-3-methyl-5-pyrazolyl N-hydroxymethyl,N-methylcarbamate and 2-methylcarbamoyl-3-methyl-5-pyrazolyl dimethylcarbamate. Three other metabolites are unidentified N-hydroxymethyl derivatives. None of these metabolites was more toxic to house flies than dimetilan, but 1 formaldehyde-yielding metabolite was almost as toxic as the parent material. Many metabolites were synergized in their toxicity by sesamex as was the case also with dimetilan and certain of its analogs. Af-methyl hydroxylation appears to be a major factor in the detoxication of dimetilan in insects.
Document Type: Research Article
Publication date: 1965-04-01
- Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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