Selective Insecticidal Action of Isopropyl Parathion and Analogues

Authors: METCALF, R. L.; FREDERICKSON, MARY

Source: Journal of Economic Entomology, Volume 58, Number 1, February 1965 , pp. 143-147(5)

Publisher: Entomological Society of America

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Abstract:

The comparative susceptibility of honey bees, Apis mellifera L., and house flies, Musca domestica L., to a series of substituted phenyl dialkyl phosphorothionates was investigated by topical applications. The p-nitrophenyl diisopropyl phosphorothionate (isopropyl parathion) was only about 0.005 as toxic to the bee as to the fly, although the corresponding dimethyl, diethyl, and dipropyl analogues were nearly equitoxic to both species. Similar selectivity associated with isopropyl esters was demonstrated for several other series of phosphorothionate compounds. The biochemical basis for this selectivity was studied. The lowered activity of isopropyl parathion to the bee appears to be the overall result of a decreased rate of in vivo oxidation to the lethal p-nitrophenyl diisopropyl phosphate together with a decreased affinity of this latter compound for bee cholinesterase.

Document Type: Research Article

Publication date: February 1, 1965

More about this publication?
  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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