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Laboratory Evaluation of Promising Systemic Insecticides in Guinea Pigs Against Oriental Rat Fleas

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Fourteen systemic insecticides administered orally caused complete mortality of oriental rat fleas, Xenopsylla cheopis (Rothschild), without noticeably affecting the guinea pigs. These compounds and the lowest effective dosages were: American Cyanamid 12503, O,O-diethyl O-[6-(3(2- phcnyl) -pyridazinonyl) ] phosphorothioate, 200 mg/kg; American Cyanamid 18706, S-ethylcarbamoylmethyl O,O- dimethyl phosphorodithioate, 100 mg/kg; American Cyanamid CL-26691, O,O-dimethyl O-p-sulfamoylphenyl phosphorothioate, 5 mg/kg; American Cyanamid CL-28865, dimethyl p-sulfamoylphenyl phosphate, 25 mg/kg; Famophos, O-p-- (dimethylsulfamoyl)phenyl O,O-dimethyl phosphorothioate, 100 mg/kg; American Cyanamid CL-38106, O,O-dimethyl O-[p- (methylsulfamoyl)phenyl] phosphorothioate, 25 mg/kg; Bayer 23655, O,O-dimethyl-S- (2-isopropyl) ethylsulfinyl thiolphosphate, 50 mg/kg; Bayer 25198, O,O-dhnethyl O-£-methylsulfinyl)phenyl phosphorothioate, 100 mg/kg; fenthion, 50 mg/kg; butonate, 50 mg/kg; dimethoate, 100 mg/kg; Monsanto CP-12432, dimethyl (1-hydroxyvinyl)phosphonate diethyl phosphate, 200 mg/kg; Vamidoate, O,O-dimethyl S-[2-[(1-methylcarbamoylethyl) thio]ethyl] phosphorodithioate, 25 mg/kg; and trichlorfon, 100 mg/kg. Three other compounds killed all the fleas, but also killed the guinea pigs. These compounds with the lowest effective dosages were: American Cyanamid CL-38064, O-p-(ethylsulfamoyl)phenyl O,Odimethyl phosphorothioate, 25 mg/kg; Meta-Systox-R®, S-2- (ethylsulfinyl)ethyl O,O-dimethyl phosphorothioate, 200 mg/kg; and diazinon, 400 mg/kg.

Document Type: Research Article

Publication date: February 1, 1965

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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