DDT-dehydrochlorinase has been demonstrated in vitro for the larvae of Aedes ageypli (L.) provided they are homogenized under glutathione and nitrogen protection. The optimum pH is 7.4. The dehydrochlorination of DDT was found to be correlated with the DDT-resistance level in strains of American origin. The same correlation was found for the dehydrochlorination of DDD, which proceeded faster, and of methoxychlor, which proceeded more slowly. The mosquito DDT-dehydrochlorinase was inhibited by DMC and WARF Antiresistant. Unlike this enzyme in the house fly, Musca domestica L., it could dehydrochlorinate o-chloro-DDT but not deutero-DDT. From DDT the only metabolite was DDE, except that highly resistant material produced a small amount of a Kelthane-like substance. In strains of Asiatic origin the dehydrochlorination of DDD but not of DDT was found proportional to the DDT-resistance ]eve!. It is however concluded that in all strains of A. aegypti DDT-dehydrochlorinaseis the principal mechanism [or DDT resistance.
Document Type: Research Article
Publication date: October 1, 1964
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Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.