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Studies with P-Labeled Bayer 22408 in Steers and Guinea Pigs

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Abstract:

Radiolabeled (P32) Bayer 22408 (O,O-diethyl O-napthalimido phosphorothioate) was applied dermally and orally to steers at 12 mg./kg. and orally and subcutaneously to guinea pigs at levels of 95 and 17 mg./kg., respectively. The compound was poorly absorbed through the skin following dermal treatment of a steer, with less than 3% of the applied dose being eliminated in the excreta within 7 days. Oral treatments of a steer indicated that a greater percentage of Bayer 22408 equivalents was eliminated in the feces than in the urine in 7 days (49% versus 41%). In guinea pigs treated orally, Bayer 22408 was eliminated at a faster rate than in the orally treated steer, and the principal excretory route was through the urine rather than the feces. In steers, the principal metabolite in the urine 2 days after treatment was diethyl phosphoric-acid, whereas the main hydrolysis product in second-day samples after treatment of guinea pigs was diethylthio phosphoric acid. or the total radioactivity in feces from both steers and guinea pigs at 1 to 5 days posttreatment, significant portions were extractable into organic solvents. Chromatographic analysis of these extracts revealed that the major portion of Bayer 22408 was slowly converted to the oxygen analog, Bayer 25820 (O,O- diethyl O-napthalimido phosphate). Bayer 22408 proved to be ineffective as a practical systemic against several important livestock pests, but information on its lack of absorption and stability as determined by the radioisotope technique aided in its further evaluation as a contact, residual insecticide.

Document Type: Research Article

Publication date: June 1, 1962

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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