Esterase Inhibition in Organophosphorus Poisoning of House Flies1

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The inhibition of hydrolysis of acetylcholine phenyl acetate, tributyrin and methyl butyrate by house flies (Musca domestica L.) has been studied at various times after poisoning by four organophosphates: parathion, malathion, DiazinonĀ® (O,O-dicthyl O-2-isopropyl-4-methyl-6-pyrimidinyl phosphorothioate) and Co-ralĀ® (O,O-diethyl O-3-chloro-4-methyl-2-oxo-2H-1-benzopyran- 7-yl phosphorothioate). In surviving flies, cholinesterase was invariably the least inhibited enzyme. But in killed flies, cholinesterase was usually the most inhibited enzyme, being 75% to 99% inactivated. The difference between enzyme levels of killed and surviving flies at any time was also greatest for cholinesterase. It is concluded that death is associated with, and probably due to, cholinesterase inhibition.

Document Type: Research Article

Publication date: December 1, 1961

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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