The Metabolism of C14 -Labeled DDT in the Larvae, Pupae, and Adults of Drosophila melanogaster1

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A metabolic product of C14-DDT in Drosophila melanogaster Meigen was found to be primarily 2,2,2-trichloro-1,l-bis-(p-chlorophenyl) ethanol, (Kelthane®), confirming the results of Tsukamoto. Kelthane was found in larvae, pupae and adults exposed to larval medium containing C14-DDT and also in adults exposed by topical application to C14-DDT. Of the two strains of Drosophila examined by adult topical exposure, one (Oregon Re) showed the active formation of Kelthane, while the other (Oregon R) did not. A new, unknown metabolite of the same chromatographic mobility as p,p'-diehlorobenzophenone was found in the larval exposure as well as a large amount of a very polar metabolite(s). Another new metabolite of the same chromatographic mobility as 2,2-dichloro-1,1-bis-(p-chlorophenyl) ethanol was found in the internal tissue extract upon adult topical exposure.

Document Type: Research Article

Publication date: February 1, 1961

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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