Oral Toxicity Studies with Heptachlor and Heptachlor Epoxide in Young Calves

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Oral toxicity studies using 13 dairy calves, 1 to 2 weeks old, showed that heptachlor epoxide was approximately 10 times as toxic as heptachlor.

Both heptachlor and heptachlor epoxide accumulated to produce poisoning when given in multiple doses. A dosage level of 0.2 mg./kg. of heptachlor epoxide for 100 consecutive days (totaling 20 mg./kg.) produced no harmful effects in a dairy calf.

The symptoms and lesions of heptachlor and heptachlor epoxide poisoning were identical to those exhibited by other cyclodiene chlorinated hydrocarbon insecticides.

Residues of heptachlor epoxide were found in the fat of all the calves treated with heptachlor or its epoxide. However, chemical analyses for heptachlor epoxide in fat were not a means of diagnosing heptachlor or heptachlor epoxide poisoning.

Document Type: Research Article

Publication date: December 1, 1959

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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