Home >> Journal of Economic Entomology, Volume 52, Number 6

Relationship between Metabolism and Differential Toxicity of Malathion in Insects and Mice

Authors: KRUEGER, H. R.; O'BRIEN, R. D.

Source: Journal of Economic Entomology, Volume 52, Number 6, December 1959 , pp. 1063-1067(5)

Publisher: Entomological Society of America

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Abstract:

An attempt has been made to account for the selective toxicity of malathion on the basis of differences in its metabolism by various species. Eleven metabolites were found in the German cockroach (Blattella germanica (L.)), and American cockroach (Periplaneta americana (L.), and house fly (Musca domestica L.), seven in the mouse. Most metabolites were identified. Degradation of malathion is much more extensive in the mouse than in the insect and malaoxon production is correspondingly lower; these effects account satisfactorily for the low toxicity of malathion to the mouse. The low toxicity of topically applied malathion to the German cockroach is attributable to poor penetration through the integument.

Document Type: Research article

Publication date: 1959-12-01

More about this publication?
  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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