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The Metabolism of Co-Ral (Bayer 21/199) by Tissues of the House .Fly, Cattle Grub, Ox, Rat, and Mouse1

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In mammals, the liver is primarily responsible for Co-ral metabolism. In the mouse, which is susceptible to Co-ral® (O,O- diethyl O-(3-chloro-4-methylumbelliferone) phosphorothionate) the compound is activated, and there are no degrading systems. In the ox and rat, which are resistant to Co-ral, the compound is degraded. It has been shown for the ox that both an activating and a degrading system are in the liver, but the latter is more potent. In the house fly (Musca domestica L.), and cattle grub (Hypoderma bovis (L.)), which are susceptible to Co-ral, there is :\n activating but no degrading system. Activation by the cattle grub is associated with fat body and gut. The results account for the selective toxicity of Co-ral, and possibly for the fact that only dermal treatment controls cattle grubs in the ox.

Document Type: Research Article

Publication date: August 1, 1959

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  • Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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