Synergistic Action of Piperonyl Butoxide with Bayer 21/199 and Its Corresponding Phosphate in Mice1
Authors: ROBBINS, WILLIAM E.; HOPKINS, THEODORE L.; DARROW, DARRELL I.
Source: Journal of Economic Entomology, Volume 52, Number 4, August 1959 , pp. 660-663(4)
Publisher: Entomological Society of America
Abstract:The joint oral Administration of piperonyl butoxide (1:5) increased the toxicity of both Bayer 21/199 (O-(3-chloro-4-methylumbelliferone) O,O-diethyl phosphorothioate) and its corresponding phosphate to mice four- to six-fold. This increase in toxicity was also found when synergist and toxicant were administered by different routes. Piperonyl butoxide increased the in vivo but not the in vitro inhibition of mouse brain cholinesterase by 21/199 or its phosphate. Preliminary studies with p32 labeled 21/199 demonstrated that the joint administration of piperonyl butoxide inhibited its metabolism to more polar metabolites.
Document Type: Research article
Publication date: 1959-08-01
- Journal of Economic Entomology is published bimonthly in February, April, June, August, October, and December. The journal publishes articles on the economic significance of insects and is divided into the following sections: apiculture & social insects; arthropods in relation to plant disease; forum; insecticide resistance and resistance management; ecotoxicology; biological and microbial control; ecology and behavior; sampling and biostatistics; household and structural insects; medical entomology; molecular entomology; veterinary entomology; forest entomology; horticultural entomology; field and forage crops, and small grains; stored-product; commodity treatment and quarantine entomology; and plant resistance. In addition to research papers, Journal of Economic Entomology publishes Letters to the Editor, interpretive articles in a Forum section, Short Communications, Rapid Communications, and Book Reviews.
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