Relationships between Structure and Synergistic Activity of Some Structural Analogs of DDT1

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Twenty-eight compounds related to DDT were evaluated as DDT synergists applied topically to a resistant strain of house flies at a dosage of 1üg. of the test compound and 5 üg. of DDT. Some of the compounds were analogs of DDT and had previously been shown to exhibit synergistic activity. The effect on synergistic activity of varying the para substituents was studied in several series of compounds.

In the p,p'-substituted diphenylmethane series, synergistic activity was destroyed if bromo-, fluoro-, methyl or nitro- was substituted for chloro-.

The para fluoro- substituted diphenylethane was inactive while the chloro- and bromo- diphenylethyl chlorides were more active than the corresponding methyl derivative, although less active than 1,1-bis(p-chlorophenyl) ethane. The diphenylethyl-enes exhibited this same activity pattern, chloro-derivatives being more active than the methyl derivative. The para chloro-, bromo- and methyl substituted diphenylvinyl chlorides were less active than their corresponding ethylenes or ethyl chlorides. The vinylidene chlorides and bromides exhibited no synergistic activity regardless of the nature of the para substituents.

Document Type: Research Article

Publication date: October 1, 1958

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